The role of mucin 1 in respiratory diseases
Por:
Ballester, Beatriz, Milara, Javier, Cortijo, Julio
Publicada:
31 mar 2021
Resumen:
Recent evidence has demonstrated that mucin 1 (MUC1) is involved in many
pathological processes that occur in the lung. MUC1 is a transmembrane
protein mainly expressed by epithelial and hematopoietic cells. It has a
receptor-like structure, which can sense the external environment and
activate intracellular signal transduction pathways through its
cytoplasmic domain. The extracellular domain of MUC1 can be released to
the external environment, thus acting as a decoy barrier to mucosal
pathogens, as well as serving as a serum biomarker for the diagnosis and
prognosis of several respiratory diseases such as lung cancer and
interstitial lung diseases. Furthermore, bioactivated MUC1-cytoplasmic
tail (CT) has been shown to act as an anti-inflammatory molecule in
several airway infections and mediates the expression of
anti-inflammatory genes in lung diseases such as chronic rhinosinusitis,
chronic obstructive pulmonary disease and severe asthma. Bioactivated
MUC1-CT has also been reported to interact with several effectors linked
to cellular transformation, contributing to the progression of
respiratory diseases such as lung cancer and pulmonary fibrosis. In this
review, we summarise the current knowledge of MUC1 as a promising
biomarker and drug target for lung disease.
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