Optical coherence tomography angiography analysis of choroidal microvasculature in various forms of diabetic macular edema
Por:
Sargues, LR, Navarro, VC, Adsuara, CM, Palop, CN, Hernández, JM, Taulet, EC
Publicada:
1 ene 2024
Ahead of Print:
1 ene 2024
Resumen:
Introduction. - Optical coherence tomography angiography (OCTA) research
in diabetic macular edema (DME) has focused on the retinal
microvasculature with little attention to the choroid. The goal of this
study was to analyze the association between quantitative choroidal OCTA
parameters and various forms of DME observed on optical coherence
tomography. Methods. - We conducted a retrospective study of 61 eyes of
53 patients with DME. DME was classified as early or advanced, and as
sponge -like diffuse retinal thickening (DRT), cystoid macular edema
(CME) or serous retinal detachment (SRD). Quantitative OCTA parameters
(vessel density [VD] in the superficial capillary plexus [SCP], middle
capillary plexus [MCP], deep capillary plexus [DCP] and choriocapillaris
[CC]) were recorded. Results. - The VD in the CC and SCP was
significantly higher in patients with early DME compared to patients
with advanced DME (P value < 0.01). CC VD was lower in subjects with SRD
compared to DRT and CME (P value < 0.001). Moreover, it was lower in CME
compared to DRT (P value < 0.05). No statistical differences were found
between VD in the MCP and DCP (P value > 0.05). Furthermore, CC VD was
lower in patients with increased retinal thickness, disruption of the
ellipsoid zone (EZ) or external limiting membrane (ELM), and
disorganization of the inner retinal layers (DRIL) (P value < 0.05).
Conclusion. - CC ischemia plays an important role in the pathogenesis of
DME. We demonstrated a decrease in CC VD in patients with severe DME,
SRD, retinal thickening, EZ and/or ELM disruption and DRIL. (c) 2023
Elsevier Masson SAS. All rights reserved.
Filiaciones:
Consorcio Hosp Gen Univ Valencia, Dept Ophthalmol, Av Tres Cruces 2,
Valencia 46014, Spain
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