Metabolomics of Plasma in XLH Patients with Arterial Hypertension: New Insights into the Underlying Mechanisms
Por:
Lopez-Romero, Luis Carlos, Broseta, Jose Jesus, Roca-Marugan, Marta, Munoz-Castaneda, Juan R., Lahoz, Agustin, Hernandez-Jaras, Julio
Publicada:
1 mar 2024
Resumen:
X-linked hypophosphatemia (XLH) is a rare genetic disorder that
increases fibroblast growth factor 23 (FGF23). XLH patients have an
elevated risk of early-onset hypertension. The precise factors
contributing to hypertension in XLH patients have yet to be identified.
A multicenter cross-sectional study of adult patients diagnosed with
XLH. Metabolomic analysis was performed using ultra-performance liquid
chromatography (UPLC) coupled to a high-resolution mass spectrometer.
Twenty subjects were included, of which nine (45%) had hypertension. The
median age was 44 years. Out of the total, seven (35%) subjects had a
family history of hypertension. No statistically significant differences
were found between both groups for nephrocalcinosis or
hyperparathyroidism. Those with hypertension exhibited significantly
higher levels of creatinine (1.08 +/- 0.31 mg/dL vs. 0.78 +/- 0.19
mg/dL; p = 0.01) and LDL-C (133.33 +/- 21.92 mg/dL vs. 107.27 +/- 20.12
mg/dL, p = 0.01). A total of 106 metabolites were identified.
Acetylcarnitine (p = 0.03), pyruvate p = (0.04), ethanolamine (p =
0.03), and butyric acid (p = 0.001) were significantly different between
both groups. This study is the first to examine the metabolomics of
hypertension in patients with XLH. We have identified significant
changes in specific metabolites that shed new light on the potential
mechanisms of hypertension in XLH patients. These findings could lead to
new studies identifying associated biomarkers and developing new
diagnostic approaches for XLH patients.
Filiaciones:
Univ Valencia, Dept Nephrol, Consorci Hosp Gen, Valencia 46014, Spain
Hosp Clin Barcelona, Dept Nephrol & Renal Transplantat, Barcelona 08036,
Spain
Hlth Res Inst Hosp La Fe IIS La Fe, Metabol Unit, Valencia 46026, Spain
Univ Cordoba, Reina Sofia Hosp, Maimonides Inst Biomed Res Cordoba
IMIBIC, Nephrol Clin Management Unit, Cordoba 14071, Spain
Hosp La Fe, Hlth Res Inst, Biomarkers & Precis Med Unit, Valencia 46026,
Hosp Univ & Politecn La Fe, Dept Nephrol, Valencia 46026, Spain
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